Abstract: Objective To detect the expressions of phosphatidylinositol 3-kinase(PI3K) P110 α and PI3Kp110β in thyroid papillary carcinoma and their relationships with prognosis.
Methods From January 2008 to July 2013,60 cases of thyroid papillary carcinoma(thyroid papillary carcinoma group),60 cases of nodular goiter(nodular goiter group) and 60 cases of other non cancerous cases were collected;the 5-year survival of papillary thyroid carcinoma group was followed up.The expressions of PI3Kp110α and PI3Kp110β protein were detected by immunohistochemistry,Kaplan-Meier survival curve was used to analyze the survival of PI3Kp110α,PI3Kp110β positive and negative groups,and Spearman method was used to analyze the correlation between PI3Kp110α and PI3Kp110β.
Results Compared with the normal group and nodular goiter group,the positive rates of PI3Kp110α and PI3Kp110β were higher in papillary thyroid carcinoma group(P<0.05).The positive expressions of PI3Kp110α and PI3Kp110β were significantly correlated with tumor size,lymph node metastasis and TNM stage(P<0.05).Single factor analysis showed that PI3Kp110α,PI3Kp110β,lymph node metastasis and TNM stage were all risk factors for poor prognosis of thyroid papillary carcinoma;multivariate analysis showed that PI3Kp110α,PI3Kp110β,lymph node metastasis and TNM stage were independent risk factors for poor prognosis of thyroid papillary carcinoma.A total of 14 cases of 60 patients had relapse,and no cases were missed.The positive cumulative survival rates of PI3Kp110α and PI3Kp110β were significantly lower than those of PI3Kp110α and PI3Kp110β(P<0.05).Spearman analysis showed that there was a positive correlation between PI3Kp110α and PI3Kp110β(P＜0.05).
Conclusion The positive rates of PI3Kp110α and PI3Kp110β in thyroid papillary carcinoma are increased,which are independent risk factors for poor prognosis,and they are closely related.

Key words: thyroid papillary carcinoma, phosphatidylinositol 3-kinase p110α, phosphatidylinositol 3-kinase p110β, prognosis