Abstract: The incidence of biliary tract cancer keeps increasing during the past years，the efficacy of palliative chemotherapy is poor and results the short overall survival period.The exploratory treatment of new chemotherapeutics such as albumin paclitaxel and three-drug combination chemotherapy has improved the chemotherapy effect of advanced biliary malignant tumors.In the past two decades，tumor genome analysis and the progress of molecular biology research clarified furtherly its pathogenesis，and with the continuous development of new drugs，those drugs such as  EGFR inhibitors，anti-angiogenesis inhibitors，MEK inhibitors，IDH1 /2 inhibitors and FGFR inhibitors have shown promising anti-tumor merit against cholangiocarcinoma.Some drugs have been approved for indications.The combination of chemotherapy and targeted therapy has also been explored.This article reviews the progress of chemotherapy and molecular targeting therapy for advanced biliary tract cancer in recent years.

Key words: biliary tract cancer, chemotherapy, molecular targeting therapy