Abstract: Objective To detect the role of LncRNA SNHG1 in human cholangiocarcinoma and explore its correlation with clinical characteristics of cholangiocarcinoma.
Methods We detected the expression of LncRNA SNHG1 in 36 human cholangiocarcinoma tissues and normal bile duct tissues by real-time PCR.And we divided the cholangiocarcinoma patients into high level SNHG1 expression group and low level SNHG1 expression group.And we analyzed the factors influencing the expression level of LncRNA SNHG1 and their relationship with survival of cholangiocarcinoma patients.
Results The expression of LncRNA SNHG1 in human cholangiocarcinoma tissues was significantly higher than the normal bile duct tissues（P＜0.05）.The lymph node metastasis was the influencing factor of LncRNA SNHG1 expression level.The ratio of low expression level of LncRNA SNHG1 was higher than that of high expression level of LncRNA SNHG1 in patients with lymph node metastasis（P＜0.05）.The age，CA19-9 expression level and expression level of LncRNA SNHG1 were an independent factor influencing the clinical prognosis of patients with cholangiocarcinoma（P＜0.05）.
Conclusion The expression of LncRNA SNHG1 is related to the distant metastasis of cholangiocarcinoma，which could be an independent risk factor for prognostic judgement and  potential therapeutic target.

Key words: cholangiocarcinoma, LncRNA, prognosis