Abstract: Objective:To evaluation the safety and efficacy of self expanding metallic stent in the treatment of complete intestinal obstruction caused by advanced colorectal cancer.Methods:The clinical data of 55 patients with complete intestinal obstruction caused by advanced colorectal cancer from 2016 to 2018 in Wuhan Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology were analyzed retrospectively.Patients were treated with selfexpanding metal stents（stent group，n=37）and surgery（surgery group，n=18）.The postoperative technical success rate，clinical success rate，length of stay，early and late adverse events and overall survival rate were statistically analyzed in both groups.Results:35 patients in the stent group achieved technical success with a technical success rate of 94.6%（35/37），while 18 patients in the surgical group achieved technical success with a technical success rate of 100%（18/18）.Clinical remission was achieved in 89.2% of patients with colon stenting and 100% of surgical patients（P＞0.05）.Compared with the surgical group，the incidence of early adverse events was significantly lower in the stent group（10.8% vs 27.8%，P＞0.05）.The mortality rate was 0 in the stent group during the hospital，compared with 5.56% in the surgical group（P＞0.05）.The average operation time（38.6min）in stent group was significantly shorter than that in operation group（123.9min）（P<0.05）.Compared with the surgery group（16 days），the average length of hospital stay（5 days）was significantly shorter（P<0.05）.The incidence of late postoperative adverse events was comparable between the two groups（13.5% vs 11.1%，P ＞0.05）.At 150 weeks，the survival rate was 29.7% in the stent group and 44.4% in the surgical group（P＞0.05）.Conclusion:Selfexpanding intestinal stent is effective in the treatment of complete intestinal obstruction caused by advanced colorectal cancer，which can significantly shorten the hospitalization time of patients，not increase postoperative complications，and greatly improve the quality of life of patients.The longterm survival of patients is comparable to palliative surgery，which is worth popularizing and applying in clinical practice.

Key words: colorectal cancer, complete intestinal obstruction, self expanding metal stent, enterostomy