Abstract: Objective To compare the content，clinical efficacy and safety of inflammatory factors in patients with acute cholecystitis treated by laparoscopic minimally invasive surgery. Methods 100 patients with acute cholecystitis admitted to our hospital from January 2015 to January 2019 were randomly selected as the study subjects.The control group was treated with traditional open cholecystectomy，while the observation group was treated with laparoscopic minimally invasive surgery.After treatment，the clinical indicators of the patients were recorded and the therapeutic effect of the patients was counted. Results The hospitalization time，intraoperative bleeding volume，operation time，recovery of gastrointestinal function and time of getting out of bed in the observation group were significantly lower than those in the control group（P<0.05）.One day after operation and seven days after operation，there were significant differences in TNF-alpha，interleukin and C-reactive protein between the observation group and the control group（P<0.05）.There were significant differences in the effective rate and the incidence of complications between the observation group and the control group（P<0.05）. Conclusion Cholecystectomy in abdominal cavity has the advantages of less trauma，less intraoperative bleeding and fast recovery of intestinal function，which can effectively reduce inflammatory response and improve the treatment effect.The operation scheme is worthy of clinical application.

Key words: laparoscopy, minimally invasive surgery, acute cholecystitis, inflammatory factors