Abstract: Objective：To investigate the clinical management strategy and clinical outcomes of kidney retransplantation.Methods：According to the clinical management strategies of kidney retransplantation of the eighth medical center of PLA General Hospital and Peking University International Hospital,a total of 17 patients who took kidney retransplantation from donation after citizen death(DCD) in both hospitals from June 2017 to June 2019 were managed in the formulated standardized strategies.The clinical outcomes such as acute rejection(AR),delayed graft function(DGF),pulmonary infection were observed.Results：14 cases(82.4%) were second kidney transplantation and 3 cases(17.6%) were three times transplantation;5 cases(29.4%) with nephrectomy and 12 cases(70.6%) with the previous kidney graft preserved;5 cases(29.4%) endured desensitization because of population reactive antibody positive and 12 cases(70.6%) were negative.There were 4 cases of AR(23.5%),6 cases of pulmonary infection(35.3%) and 1 case of DGF(5.9%).There were 1 case(20%) of AR in the nephrectomy group,1 case(20%) of pulmonary infection;3 cases(25%) of AR and 5 cases(41.7%) of lung infection in the transplantation group.In desensitization group,there were 1 case of AR(20%),2 cases of lung(40%),3 cases of AR(25%) and 4 cases of pulmonary infection(33.3%) in nondesensitization group.Median follow-up time was 14.5 months (636 months).The 1year renal survival rate was 94.1%(16/17 cases) and 1 case(5.9%) died.Conclusion：Although kidney retransplantation recipients were in immunologically high risk,reasonable and standardized clinical management strategy can achieve better clinical outcomes.There are significantly the risk of pulmonary infection after renal transplantation in patients without nephrectomy.Desensitization therapy could significantly reduce the risk of rejection after renal transplantation,and did not significantly increase the risk of infection.

Key words: kidney retransplantation, 〓acute rejection, 〓pulmonary infection