Abstract: Objective To investigate correlation between surgery and radiotherapy interval and tumor growth and prognosis in patients with new-glioblastoma.
Methods This retrospective analysis included 80 cases of new glioblastoma undergoing surgical resection from June 2013 to August 2016.They were divided into three groups,<30 days group,30-60 days group,> 60 days group,according to the postoperative radiotherapy interval.The data of the three groups were compared,and the risk of death of the three groups was analyzed by Kaplan-Meier method after 3 years of follow-up.The clinical data of the survival group and the death group were compared,and independent risk factors affecting the prognosis of the patients were analyzed using COX regression analysis.
Results During the follow-up of the three groups of patients,one case was lost to follow-up and a total of 3 cases were lost to follow-up.The <30 days group’s 3-year overall survival rate was 46.16%(12/26),and its median survival time was 32(10-36) months.The 30-60 day group’s 3-year overall survival rate was 48.00%(12/25),and its median survival time was 32(9-36) months.The 3-year overall survival rate of the 60-day group was 42.31%(11/26),with a median survival time of 30(8 ～ 36) months.Kaplan-Meier survival curve analysis showed that there was no significant difference in the three-year mortality risk between the three groups of patients(log-rank χ2 = 0.046,P= 0.977).Patients in the death group had statistically significant differences in age,KPS score,surgical resection range and survival group(P <0.05).Multivariate COX regression analysis showed that age ≥ 65 years(HR=2.162,95%CI：1.455-4.026,P=0.001),preoperative KPS score < 80 points(HR=1.634,95%CI：1.006-3.241,P=0.003),and partial surgical resection(HR=3.241,95%CI：2.343-5.862,P＜0.001) were risk factors for new GBM deaths(P<0.05).
Conclusion  For patients with new-onset glioblastoma,the interval between postoperative and radiotherapy has no significant effect on the prognosis,but age,KPS score before surgery,and the extent of surgical resection will affect the patient’s poor prognosis.

Key words: glioblastoma, postoperative radiotherapy time, prognosis, surgical resection