Abstract: Objective:To explore the correlation between chronic schistosomiasis and colorectal cancer.Methods:60 patients with single colorectal cancer（group A）and 60 cases of chronic schistosomiasis were selected（group B）.In this paper，two groups of serum CEA levels were obtained by doublesite sandwich chemiluminescence immunoassay，and the two groups were divided according to the TNM stage standard of colorectal cancer； the two groups were classified according to the histological grade standard of colorectal cancer，and the difference was analyzed.Results:In the comparison of high age，the proportion of group A（13.33%）was higher than that of group B（11.67%）（P＞0.05）； and the level of CEA in group A was higher than that of group B in stage Ⅰ，stage Ⅱ and high differentiation stage（P<0.05）.There was no difference in CEA level between group A and group B in stage Ⅲ，stage Ⅳ and middle and low differentiation stages（P>0.05）.Conclusion:The main difference between the single colorectal cancer group and the group with chronic schistosomiasis in the early stage of colorectal cancer，and chronic schistosomiasis affects the occurrence of colorectal cancer.

Key words: chronic schistosomiasis, colorectal cancer