Abstract: Objective:To explore the content change of IL1β and to investigate the role of IL1β on the hepatic function damage of acute pancreatitis.Methods:Sixty patients of nonbiliary acute pancreatitis with hepatic function damage from Sept 2015 to Sept 2017，according to CT grading divided into mild acute pancreatitis（MAP）with 30 cases and severe acute pancreatitis（SAP）with 30 cases，selected 30 cases of healthy people as the control group.By using automatic bichemical analyzer to test the level of ALT and AST，using  radioimmunoassay to test the level of IL1β，then  statistical analysis was conducted.Results:The level of ALT、AST and IL1β in MAP and SAP group were higher than in the control group（P<0.05），the level of ALT、AST and IL1β in SAP group were higher than in the MAP group，all had statistical significance（P<0.05）.Conclusion:IL1β may be involved in the process of hepatic function damage with acute pancreatitis，and the level of  IL1β is positively correlated with the severity of hepatic function damage.

Key words: acute pancreatitis, hepatic function damage, IL1β