Abstract: Objective:To investigate the clinicopathological characteristics and the meaning of staging evaluation by the prognostic staging system of breast cancer with different molecular types.Methods:Clinicopathologic data of 236 breast cancer cases，which confirmed by surgical treatment.2018.According to the 2017 CACA guidelines of breast cancer diagnosis and treatment distinguished different molecular subtypes，and compared clinicopathological characteristics of different molecular subtypes.The study reappraised the anatomic staging and prognostic staging according to the AJCC staging criteria for breast cancer，and compared the changing characteristics of prognostic staging in different anatomical stages of each molecular subtype.Results:The study found different subtypes show statistical significant differences in histological grading、 Ki67 level、lymph node metastasis、anatomical stage and prognosis stage（P＜0.05），but not in tumor size（P＞0.05）.Compared with anatomical stage，the prognosis stage changed，and there were statistical significant among subtypes（P＜0.05）.The changing characteristics of prognostic staging in different anatomical stages of each molecular subtype is significant（P＜0.05）.Conclusion:There is heterogeneity among different molecular subtypes.Compared with anatomical stage，the changing characteristics of prognostic staging is vary from molecular subtype.Molecular typing combined with prognostic staging maybe provided an important basis for accurated individualized treatment of breast cancer.

Key words: breast cancer, molecular subtypes, 8th AJCC breast cancer staging system, prognosis