Abstract:

Objective:LTo explore the relationship between the ultrasound findings of breast cancer and the expression of CerbB2，vascular endothelial growth factor（VEGF）and nm23 and their clinical significance.Methods:A total of 102 patients with breast lesions were enrolled.87 patients were diagnosed with breast cancer by pathological examination.All patients underwent contrastenhanced color Doppler ultrasonography，and immunohistochemistry was used to detect the expression levels of CerbB2，VEGF and nm23 in tumor tissues.The ultrasound characteristics of each patient were evaluated and compared to the expression of CerbB2，VEGF and nm23.Results:Ultrasound examination showed that the tumor had calcification，burr signs，vascular abnormalities and lymphatic metastasis，etc.These symptoms were associated with high expression of CerbB2，VEGF，and nm23（P<0.05），whereas calcification was not associated with high expression of these biomarkers（P>0.05）.For patients with high expression of CerbB2 and VEGF，the timeintensity peak（TTP）curve is shorter and the peak intensity（PI）is higher.In contrast，patients with high expression of NM23 had significantly longer TTP and lower PI（P<0.05）.Conclusion

:The ultrasound characteristics of breast cancer are related to the expression of CerbB2，VEGF and nm23.Predictive expression of CerbB2，VEGF and nm23 based on ultrasound characteristics of patients.Then adjuvant evaluation of therapeutic effect and prognosis of breast cancer.

Key words: breast cancer, ultrasound characteristics, vascular endothelial growth factor, expression