Abstract: Peritoneal metastasis is very common in patients with advanced colorectal cancer and is the second most common site of metastasis in colorectal cancer.Traditionally,it is considered to be poor in prognosis and has no value of surgical treatment.With the progress of surgical techniques,precision temperature controlled intraperitoneal perfusion chemotherapy and multidisciplinary comprehensive treatment,the recognition and treatment strategy of peritoneal metastasis of colorectal cancer has changed greatly.The introduction of new chemotherapy drugs and targeted biological agents has improved the prognosis of patients with metastatic colorectal cancer.It is worth noting that the combination of cytoreductive surgery(CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC) with systemic therapy is the current standard therapy,which effectively extends the survival period of patients with colorectal cancer with peritoneal metastasis.This review focused on the current application value and research progress of CRS and HIPEC in peritoneal metastasis of colorectal cancer.

Key words: colorectal cancer, peritoneal metastasis, cytoreductive surgery, hyperthermic intraperitoneal chemotherapy