Abstract: Objective To investigate the success rate and safety of endoscopicallyassisted local resection of duodenal tumors，and to provide basic background parameters for clinical studies.Methods Cases of endoscopicallyassisted local resection of duodenal tumors were collected from the hubei cooperation group of endoscopic surgery that could perform routine intraoperative endoscopic examination and treatment for duodenal tumors from January 1，2015 to December 31，2018.Final treatment of planned local excision cases and complications were counted.Results A total of 45 cases，9 cases had been founded the tumor location in the duodenal bulbar，26 cases the tumor location in the descending part of duodenum，4 cases in the horizontal part of duodenum，6 cases in the end of the duodenal or start segment of jejunum.Complete resection of the lesion was completed in all the 45 cases for local resection.17 cases performed by exploratory laparotomy，3 cases performed by robotic assisted the duodenal partial resection，14 cases performed by laparoscopic duodenal partial resection，6 cases performed by complete endoscopic resection and 5 cases performed by endoscopic resection combined withlaparoscopic repaired.2 cases of postoperative complications were all occurred in the descending part of the duodenum.A case tumor of the middle and lower descending duodenum occurred anastomotic leakage，abdominal bleeding and incision infection after surgery.After two operations，he was discharged from hospital.Another case tumor of upper and middle descending duodenum occurred pancreatic wound bleeding，and hemostasis was stopped by suture.Conclusions With the support of endoscopic technology，local resection of duodenal tumors can be performed in a variety of surgical methods，and it is difficult to define the feasibility standard of local resection simply by the size or location of the tumor.

Key words: duodenum, tumor, local resection, pancreaticoduodenectomy