Abstract: [Abstract]  objective    To analyze the risk factors of anastomotic leakage after treatment of radical esophagectomy for esophageal cancer.Methods  The clinical data of 381 patients with esophageal cancer undergoing radical esophagectomy were analyzed retrospectively.Gender，age，ASA score，previous hypertension，diabetes history，surgical condition，preoperative and postoperative laboratory test results，and other factors that may affect the occurrence of anastomotic leakage after esophageal cancer were selected for univariate analysis.Logistic regression was used to analyze the main risk factors.Results  Thirtyseven patients of 381 cases with esophagectomy occurr ed anastomotic leakage and the incidence rate was 9.7%（37/381）.In univariate analysis，tumor location，surgery type，anastomotic site，smoking，moderately severely COPD，bleeding volume，operating time and the CRP on second day after operation were determined as influence factors.The multivariate analysis showed that anastomotic site，smoking，bleeding volume and the CRP on second day after operation are independent risk factors for anastomotic leakage after esophagectomy.ConclusionAnastomotic site，bleeding volume and smoking are important factors for the anastomotic leakage，and the CRP on second day after operation is a    useful marker of prediction about early anastomotic leakage of esophagectomy.

Key words:  ,  , percutaneous nephrolithotomy holmium laser lithotripsy, microchannels, standard channels, complex renal stones