Abstract: Objective:To analyze the clinical and radiological data of microcalcificationrelated breast cancer in fullfield digital mammography，explore the risk factors and in order to improve the diagnosis and treatment of suspicious microcifications.Methods:Clinical data and radiological characteristics were analyzed retrospectively in 447 cases of breast lesions，whose pathology were confirmed by operation.The clinical and imaging data were analyzed to compare their differences in benign and malignant lesionsResults:A total of 93 cases of breast cancer were detected（20.8%），52 cases were intraductal carcinoma（11.6%），12 cases were invasivel carcinoma（4.7%），29 cases were intraductal carcinoma with infiltration（6.5%）.A total of 354 cases were benign lesion（79.2%），297 cases were hyperadenosis（66.4%），37 cases were fibroadenoma（8.3%），10 cases were intraductal papilloma（2.2%），4 cases were duct ectasia（0.9%），4 cases were interstitial chronic inflammation（0.9%），2 cases were sclerosing adenopathy（0.4%）.There were significant differences in microcalcifications between benign and malignant breast lesions according to position、distribution、shape、density、range and BIRADS（P<0.05），larger differences were shown in distribution、shape and BIRADS（P<0.05）.Conclusion:The distribution（grouped and linear/segmental）、shape（fine pleomorphic and finelinear/finelinear branch）and BIRADS（4 and 5 category）of the microcalcification are the important factors affecting pathological results，aggressive multimodality therapy is warranted to improve prognosis.

Key words: fullfield digital mammography, microcalcification, breast cancer, diagnosis, treatment