Abstract: Objective    To analyze outcomes and effect of endoscopic endonasal transsphenoidal surgery for 52 patients with prolactinsecrecting pituitary adenoma. Methods  52 patients treated with endoscopic transsphenoidal surgery were collected and postoperative efficacy and related influencing factors were analyzed.Results The clinical symptoms and levels of prolactin were significantly improved in the 52 patients after operation.The total removal rate of 52 patients was 61.5%（32），and compared with the giant adenomas（35.7%），the total removal rate of microadenomas （100%）and large adenomas（68.6%） was significantly higher（P<0.05）.The total resection rate between invasive（29.2%） and noninvasive prolactin adenomas（89.3%） was significantly different（P<0.05）.The total remission rate of 52 patients was 65.4%（34），and there was no significant difference in the remission rate（76.9%，62.5%，40.0%） of preoperative prolactin levels groups（P>0.05）.There was no significant difference in the postoperative remission rate among patients of different ethnic groups（P>0.05）.Taking bromocriptine before surgery had no significant effect on the surgical outcome，the difference was not statistically significant（P>0.05）.There were no complications such as cerebrospinal fluid rhinorrhea，visual field defects，or decreased visual acuity after surgery.No patient died.Conclusion  The tumor size and invasiveness were important factors for influencing the surgery effect.Taking bromocriptine before surgery had little effect on the surgical outcome.There was no significant difference for postoperative efficacy in different ethnic group，and the total cut rate and the decrease degree of postoperative PRL are closely related with the recurrence of tumor.

Key words: neuroendoscopy, endonasal transsphenoidal surgery, prolactin adenoma, surgical treatment