Abstract: Objective To investigate the clinical effect of high ligation of great saphenous vein combined with endovenous laser closure and foam sclerotherapy in the treatment of chronic varicose veins of lower extremities.Methods  80 patients with varicose veins of lower extremities in our department were selected and divided into two groups（40 cases）according to different surgical methods.Among them，the study group was treated with high saphenous vein ligation plus foam sclerotherapy plus endovenous laser closure，and the control group（treated by high saphenous vein ligation plus endovenous laser closure）.The clinical effects of the 2 groups were compared.Results  The operation time，intraoperative bleeding volume，incision number，hospitalization time，〖JP2〗visual analogue score，hospitalization expenses and complications in the study group were （57.8±13.3）min，（9.6±2.5）ml，（3.6±1.2），（4.2±1.2）d，（6.4±1.4），（6820.4±610.4）yuan，5.0%，respectively.They were significantly less than those in the control group which were （44.5±14.5）min，（15.3±4.2） ml，（7.9±2.0），（6.4±2.1） d，（8.2±1.6），（7381.2±731.6）yuan，20.0%，respectively.After treatment，FIB，tPA，PAI1，PAI1，PAI1，IL10，IL10，IL10 and IL2 of study group were （3.0±0.2）g/L，（24.2±3.1）ng/L，（35.9±4.2）ng/L，（157.2±23.3）pg/ml and（125.3±15.2）pg/ml，respectively.Which were better than control group[（3.4±0.3）g/L，（20.5±3.0）ng/L，（42.4±3.6）ng/L，（131.5±17.0）pg/ml，（142.8±17.0）pg/ml）]，there were significantly improved（P<0.05）.Multivariate logistic regression analysis showed that the risk factors associated with recurrence after operation included saphenous vein diameter >1cm，left iliac vein pressure，elastic socks wearing time <3months，varicose vein diameter >2cm，venous mass treatment >2 times 〖LM〗and location.Closed small saphenous vein.Conclusion Foam sclerotherapy combined with EVLT is effective in the treatment of varicose veins of lower extremities，and can improve coagulation function and reduce inflammatory reaction.

Key words: endovenous laser closure, 〓 foam sclerosing agent, 〓 varicose veins of lower extremities