Abstract: Objective To find out the future research hotspot and trends of gastrointestinal stromal tumors（GISTs）research.Methods  Data were based on the Science Citation Index Expanded（SCIE），from the Institute of Scientific Information Web of Science database.Articles referring to GISTs during 20082017 were concentrated on the analysis of the number of papers published,number of pages of papers,number of citations,number of citations,the number of countries involved in the study of gastrointestinal stromal tumor,the number of journals and periodicals ranked among the top 20 in terms of the number of papers related to gastrointestinal stromal tumor,and the number of keywords in the top 32 in terms of the accumulated number.Results  This searching strategy located 10，440 publications on GISTs in the SCI database.The cumulative number of publication followed linear distribution（R2=0.9994）.The three most prolific journals are Journal of Clinical Oncology and Annals of Oncology，responsible for 5.88 % of the publication.The change trends of author keywords may reveal the changes of research spots.Conclusion  DOG1 and immunotherapy will undoubtedly maintain the hotspots of GISTs research in the next few decades.