Abstract: [Abstract]  Objective To study the curative effect，gallbladder，liver function and living quality between cholecystolithotomy with gallbladder reservation by laparoscopy and choledochoscope and laparoscopic cholecystectomy in gallbladder stone patients with colecystolithiasis.Methods 60 patients with gallbladder stone were selected and they were divided into research group（n=30）and control group （n=30）according to different surgical operation way.Research group was treated by laparoscope combined with choledochoscope while control group was treated by totally laparoscope for gallbladderprotected lithotomy.The curative effect and so on were observed in the two groups. Results The curative effect between research group（96.67%）and control group（93.33%）which had no statistically significant difference（P>0.05）.Operation time and removal rate of calculi in research group were obviously longer than that of control group，and blood loss wassignificantly less than that of control group，the difference was statistically significant （P<0.05），but two groups of intestinal peristalsis recovery time 、hospitalization days and postoperative complications had no statistically significant difference （P>0.05）.The fasting gallbladder volume and maximum shrinkage 12 months after operation were better in the research group than those in the control group（P<0.05）.The liver function in two groups had no statistically significant difference before and 1 month after operation（P>0.05）.The living quality in in the research group were higher than the control group 12 month after operation（P<0.05）.Conclusion Choledochoscopeassisted laparoscopic surgery for gallstones is safe and effective for the recovery of gallbladder and liver function，at the same time it can improve the living quality of patients，thus should be widely applied.

Key words: bile duct injuries, biliary intestinal anastomosis, preventive ,