Abstract: [Abstract] Objective  To investigate the effects and significance of serum amylase，prealbumin （PAB）and albumin （ALB）in the treatment of acute pancreatitis （AP）with amino acid support in ERCP（encoscopic retrograde cholangiopancreatography）.Methods 100 patients with acute pancreatitis diagnosed by ERCP were randomly divided into two groups（n=50）.The control group was given routine surgical treatment.On the basis of this，the treatment group was deal with parenteral amino acid nutrition for 7 days.The serum amylase level was measured at 2h before operation，2h，1d，2d and 7d after operation，and the curative and symptom effect were observed.Results  Compared with the control group，the serum amylase levels，main clinical symptoms，and nutritional status indicators were significantly relieved in the observation group（P<0.05）.Compared with the control group，the total effective rate of the treatment group was significantly increased，the difference was statistically significant（P<0.05）.Conclusion ERCP treatment of acute pancreatitis to give amino acid nutritional support treatment could effectively relieve the clinical symptoms of AP，and reduce the content of serum amylase.

Key words: colon cancer, intracorporeal anastomosis, natural orifice specimen extraction surgery