Abstract: Objective  To investigate the analgesic effect of multi-site multiple paravertebral nerve blocks on patients undergoing radical lung cancer surgery and the impact on their serum indices and prognosis.Methods Ninety-eight cases of patients undergoing thoracoscopic radical lung cancer surgery in our hospital were selected from March 2021 to January 2023 and divided into 2 groups according to the difference in anaesthesia.Among them,42 patients in the study group were treated with preoperative and postoperative multipoint paravertebral nerve block combined with general anaesthesia,while 56 patients in the control group were treated with preoperative multipoint paravertebral nerve block combined with general anaesthesia,and the analgesic effect and other differences between the two groups were compared.Results  In the study group, extubation time, recovery time, propofol dosage and postoperative VAS score were (150.2±15.2) min, (19.1±5.1) min, (738.2±36.5) mg and (4.2±0.7) points, respectively.The control group was (151.9±12.6) min, (22.6±7.3) min, (902.1±49.0) mg and (2.3±0.3) min, respectively, and the difference between the two groups was statistically significant (P<0.05).The differences of heart rate, mean arterial pressure and before and after half an hour after surgery in control group were higher than those in study group, and the differences of norepinephrine, epinephrine and before and after surgery were higher than those in study group, with statistical significance (P<0.05).The total complication rate of the study group was 7.2%, and that of the control group was 23.2%. The QoR score of the control group was lower than that of the study group, and the difference between the two groups was statistically significant (P<0.05).Conclusion  Preoperative and postoperative multi-point paravertebral nerve block combined with general anaesthesia has a better analgesic effect on patients undergoing radical lung cancer surgery,which can not only reduce the inflammatory reaction of the patients,but also have less impact on their haemodynamic indexes and lower rate of postoperative adverse reactions,and ultimately improve the quality of life of the patients.

Key words: paravertebral nerve block, radical lung cancer surgery, analgesic effect, serum index, complication