Abstract: Objective  To investigate the efficacy of micrornas (miR)27B-3P combined with miR-215 in predicting the recurrence of early gastric cancer after endoscopic submucosal dissection (ESD).Methods A total of 122 patients with early gastric cancer admitted to the hospital from January 2021 to February 2022 were selected.All patients received ESD surgery and were followed up for 10~15 months, average (12.57±1.83) months.Patients with early gastric cancer were divided into recurrence group and non-recurrence group according to whether they had recurrence after ESD surgery.The relative expression levels of miR-27b-3p and miR-215 and clinical data of the two groups were compared to analyze the factors affecting the recurrence of early gastric cancer patients after ESD surgery,and analyze the relative expression levels of miR-27b-3p and miR-215 and the predictive value of their combination for the recurrence of early gastric cancer patients after ESD surgery.Results  After 10~15 months, average (12.57±1.83) months of follow-up,3 cases of 122 patients were lost to follow-up,the follow-up rate was 97.54%,of which 12 cases relapsed,and the remaining 107 cases did not relapse.The miR-27b-3p in the relapsed group was lower than that in the non-relapsed group (P<0.05),and the relative expression of miR-215 in the relapsed group was higher than that in the non-relapsed group (P<0.05).The proportion of patients with lesion size ≥3cm and infiltration depth of SM2-SM3 in recurrence group was higher than that in non-recurrence group (P<0.05),and the proportion of patients with R0 resection in recurrence group was lower than that in non-recurrence group (P<0.05).Logistic multivariate regression analysis showed that the lesion size was ≥3cm  and the depth of invasion was SM2-SM3 ,the relative expression level of miR-27b-3p ,the relative expression level of miR-215  were the influential factors for recurrence of early gastric cancer patients after ESD operation (P<0.05).The relative expression levels of miR-27b-3p and miR-215 and their combined prediction of the area under the curve (AUC) of ESD postoperative recurrence in early gastric cancer patients were 0.783,0.845 and 0.935,respectively.Conclusion  miR-27b-3p and miR-215 can be used to predict the recurrence risk of early gastric cancer patients after ESD surgery,and the combination of Mir-27B-3P and Mir-215 has higher predictive value.

Key words: Microrna-27B-3P, Microrna-215, early gastric cancer, endoscopic submucosal dissection, recurrence, predictive value