Abstract: Objective To observe the expression changes of forkhead box C1(FOXC1) and SRY-related HMG-box 11(SOX11) in the normal and cancerous tissues of patients with cardiac cancer,and to explore the relationship between their expression and clinical pathological characteristics and prognosis.Methods A total of 94 patients with cardiac cancer diagnosed in our hospital from March 2018 to March 2020 were collected and grouped into survival group(n=54) and death group(n=40) based on their mortality within 3 years. All patients underwent laparoscopic proximal gastrectomy and gastroesophageal anastomosis. Immunohistochemical Methods were applied to detect the expression levels of FOXC1 and SOX11 in tissues,analysis of the relationship between FOXC1,SOX11 expression levels and 3-year overall survival rate in gastric cardia cancer patients using Kaplan Meier method,and Cox risk regression model was applied to analyze the influencing factors of 3-year prognosis in patients with cardiac cancer.Results The positive expression rate of FOXC1 in cancer tissue of patients with cardiac cancer was higher than that in normal tissues,the positive expression rate of SOX11 was lower than that in normal tissues(P＜0.05).The positive expression rate of FOXC1 and negative expression rate of SOX11 in cardiac cancer tissues of patients with pathologic stage III+IV,poorly differentiated tissues,and lymph node metastasis were obviously higher than those of patients with pathologic stage Ⅰ+Ⅱ,moderately/well differentiated tissues,and no lymph node metastasis(P＜0.05).The proportions of patients with pathologic stage Ⅲ+Ⅳ,lymph node metastasis,positive expression of FOXC1,and negative expression of SOX11 in the death group were higher than those in the survival group(P＜0.05).The 3-year overall survival rate of patients with FOXC1 positive expression in cardiac cancer tissue was lower than that of patients with FOXC1 negative expression(P＜0.05);The 3-year overall survival rate of patients with negative SOX11 expression in cardiac cancer tissue is lower than that of patients with positive SOX11 expression(P＜0.05).FOXC1 was an independent risk factor for death in cardiac cancer patients during a 3-year follow-up period,while SOX11 was a protective factor for death in cardiac cancer patients during a 3-year follow-up period(P＜0.05).Conclusion High expression of FOXC1 and low expression of SOX11 may be involved in the occurrence and development of cardiac cancer,which is closely related to poor prognosis of patients.

Key words: cardiac cancer; forkhead box C1; SRY-related HMG-box 11; clinical pathological characteristics; prognosis