Abstract: Objective  To explore the diagnostic efficacy of magnetic resonance imaging(MRI) combined with serum carbohydrate antigen 125(CA125) and angiopoietin like protein 2(ANGPTL2) in breast cancer.Methods  From February 2020 to June 2022,152 patients with breast diseases diagnosed initially in our hospital were collected as the subjects of this study.According to the results of pathological tissue examination(breast cancer modified radical mastectomy operation or needle biopsy),they were grouped into breast cancer group(90 cases) and benign group(62 cases).All patients underwent MRI examination.Measurement of serum CA125 and ANGPTL2 levels;receiver Operating Characteristic curve (ROC) were analysed for the critical diagnostic points of breast cancer by MRI combined with serum CA125 and ANGPTL2;and four grid table was applied to analyze the diagnostic value of MRI combined with serum CA125 and ANGPTL2 in breast cancer.Results  The ring enhancement in breast cancer group was obviously higher than that in benign group(P<0.05),and the uniform enhancement in benign group was obviously higher than that in breast cancer group(P<0.05).The levels of serum CA125 and ANGPTL2 in breast cancer group were obviously higher than those in benign group(P<0.05).According to the ROC,the AUC of serum CA125 in the diagnosis of breast cancer was 0.870(95%CI:0.815~0.924) and the cut-off value was 29.574 U/ml,the AUC of serum ANGPTL2 CA125 in the diagnosis of breast cancer was 0.893(95%CI:0.843~0.942),the cut-off value was 6.085 ng/ml,and the AUC of MRI diagnosis of breast cancer was 0.891（95%CI:0.832~0.950）.The accuracy of MRI,CA125,ANGPTL2 and combination of three indexes in the diagnosis of breast cancer were 89.47%,84.87%,82.89%,93.42% respectively.Conclusion  MRI combined with serum CA125 and ANGPTL2 can improve the diagnostic efficacy of breast cancer.

Key words: magnetic resonance imaging, carbohydrate antigen 125, angiopoietin like protein 2, breast cancer, diagnosis