Abstract: Objective  To investigate the correlation between the expression of hsa_circ_0001785 in triple negative breast cancer(TNBC) and the efficacy of neoadjuvant chemotherapy(NAC).Methods  A total of 129 patients with triple negative breast cancer who were admitted to our hospital from October 2021 to February 2023 were regarded as the study group，and 125 patients with benign breast lesions who underwent surgery in our hospital were served as the control group.The influencing factors of NAC efficacy in TNBC patients were analyzed by multivariate  logistic  regression model;receiver operating characteristic(ROC) curve was applied to analyze the predictive value of hsa_circ_0001785 level for NAC efficacy in triple negative breast cancer patients.Results  Compared with the control group(1.05±0.16)，the expression level of hsa_circ_0001785 in the study group(2.47±0.39) increased(P＜0.05);compared with the effective group(2.34±0.35)，the expression level of hsa_circ_0001785 in the ineffective group(3.48±0.56) increased(P＜0.05);hsa_circ_0001785 was highly expressed in triple negative breast cancer patients with tumor diameter＞2cm，lymph node metastasis and high tissue grade(P<0.05);high expression of hsa_circ_0001785，tumor diameter＞2cm，occurrence of lymph node metastasis and high histological grade were risk factors for NAC efficacy in triple negative breast cancer patients(P<0.05).Hsa_circ_0001785 level has certain predictive value for NAC efficacy in TNBC patients.Conclusion  Hsa_circ_0001785 is highly expressed in triple negative breast cancer,and the level of hsa_circ_0001785 has a certain predictive value for the efficacy of NAC in patients.

Key words: triple negative breast cancer, hsa_circ_0001785, neoadjuvant chemotherapy, efficacy, predictive value