Abstract: Objective To analyze the incidence and risk factors of intraperitoneal infection in patients with hepatocellular carcinoma combined with cirrhosis and portal hypertension undergoing laparoscopic surgery.Methods The clinical data of 105 consecutive cases of laparoscopic devascularization combined with hepatectomy or radiofrequency ablation were retrospectively analyzed.The factors that may cause intraperitoneal infection were recorded.The postoperative recovery was observed and the incidence of intraperitoneal infection was recorded.Single factor and logistic regression multivariate analysis were used to screen independent risk factors for intraperitoneal infection.Results The incidence of intraperitoneal infection was 17.14%.Diabetes,MELD score,intraoperative bleeding and postoperative ascites were independent risk factors for intraperitoneal infection (P＜0.05).Conclusion  It is necessary to strengthen liver function maintenance,intraoperative bleeding control,reduce the third space effusion and blood sugar management of patients with diabetes to reduce intraperitoneal infection.

Key words: hepatocellular carcinoma, liver cirrhosis, portal hypertension, surgery, intraperitoneal infection