Abstract: Objective To explore the predictive effect of serum Stromal cell-derived factor 1 (SDF-1)and C-X-C chemokine receptor type 4(CXCR4)on early hematoma enlargement in hypertensive intracerebral hemorrhage(HICH).Methods The clinical data of 79 patients with HICH in our hospital from January 2020 to June 2022 were retrospectively analyzed.According to the results of head CT reexamination after admission,the patients were divided into hematoma enlargement group and hematoma non enlargement group.The hematoma location of the first head CT examination,hematoma shape,systolic blood pressure level after admission,hematoma density uniformity,admission GCS score and serum SDF-1 and CXCR4 were compared between the two groups.Receiver operator characteristic curve (ROC) was used to evaluate the predictive value of SDF-1 and CXCR4.Results Among 79 patients with HICH,21 patients had increased bleeding.Univariate analysis showed that there were significant differences in hematoma shape,admission GCS score,systolic blood pressure and hematoma density between the two groups (all P<0.05).Logistic multivariate analysis showed that SDF-1 and CXCR4 were independent risk factors for hematoma enlargement in early stage of hypertensive intracerebral hemorrhage (respectively OR:1.460,1.362,respectively 95%CI:1.056 ~ 2.018,1.200 ~ 1.547,all P<0.05).ROC curve analysis showed that AUC of SDF-1 was 0.868 (95%CI:0.688-1.000,P<0.005),specificity was 0.875,sensitivity was 0.778.The AUC of CXCR4 was 0.758 (95%CI:0.557-0.948,P<0.05),the specificity was 0.750,and the sensitivity was 0.733.Conclusion The expression of SDF-1 and CXCR4 in patients with HICH is significantly increased,which is related to the early hematoma enlargement.SDF-1 and CXCR4 have high sensitivity and specificity in predicting the early hematoma enlargement in HICH.

Key words: hematoma enlargement, hypertensive cerebral hemorrhage, stromal cell-derived factor 1；C-X-C chemokine receptor type 4