Abstract: Objective   To analyze the effect of remazolam on serum malondialdehyde (MDA),superoxide dismutase (SOD) and glutathione peroxidase (GSH Px) levels in patients undergoing laparoscopic cholecystectomy.  Methods   From december 2021 to november 2022,110 patients undergoing laparoscopic cholecystectomy in our general surgery department were divided into propofol group and ramazolam group according to the random number table method.55 patients in the propofol group were anesthetized with propofol for induction and maintenance,55 patients in the ramazolam group were anesthetized with ramazolam for induction and maintenance.The vital signs(mean arterial pressure, heart rate),indexes of anesthesia awakening(eye opening time, orientation recovery time, extubation time),indexes of oxidative stress(MDA, SOD, GSH Px),cognitive function(MMSE score) and adverse reactions(respiratory depression, restlessness, dizziness, headache, hypotension, drowsiness) of the two groups were compared.  Results   The mean arterial pressure and heart rate at the time of intubation,pneumoperitoneum and extubation in the ramazolam group were higher than those in the propofol group (P＜0.05).The time of eye opening,recovery of orientation and extubation in remiazolam group [(10.37±2.15)min,(10.83±2.41)min,(11.06±2.19)min] were shorter than those in propofol group [(12.44±2.78)min,(13.16±2.84)min,(14.78±2.55)min] (P＜0.05).The level of MDA at 1 day after surgery in remiazolam group [(19.73±2.32)mmol/L] were lower than those in propofol group [(27.82±2.95)mmol/L],and the level of SOD and GSH Px in remiazolam group [(310.85±27.61)U/ml,(939.63±105.14)U] were higher than those in propofol group [(275.33±24.97)U/ml,(844.73±96.30)U](all P＜0.05).MMSE score of remiazolam group (26.89±1.00) was higher than that of propofol group (25.33±0.92) on the first day after operation (P＜0.05).The incidence of adverse reactions in remidazolam group was 7.27%,lower than 21.82% in propofol group(P＜0.05).  Conclusion   Remazolam is effective in anesthesia of laparoscopic cholecystectomy.It can stabilize the vital signs of patients,improve the quality of recovery from anesthesia,reduce oxidative stress reaction and cognitive function damage,and has few adverse reactions.

Key words: remazolam, laparoscopic cholecystectomy, malondialdehyde, superoxide dismutase, glutathione peroxidase