Abstract: Objective To investigate the effects of early enteral nutrition support with different energy ratios on nutritional indices and immune function in patients with severe brain injury. Methods 71 patients with severe craniocerebral injury admitted to our hospital from November 2018 to November 2021 were selected as the research objects.According to the different energy of enteral and intralteral nutrient solution,they were divided into low energy group (n=36) and high energy group (n=35).Patients in the low energy group received early 50% low energy enteral and intralteral nutrition support.Patients in the high energy group received early 100% high energy parenteral nutrition support.Nutritional indexes hemoglobin (Hb),total protein (PA),serum albumin (Alb),transferrin (TF),immune indexes [(immunoglobulin A (IgA),immunoglobulin M (IgG),immunoglobulin M (IgM),T lymphocyte subsets CD3+,CD4+,CD8+ and CD4+/CD8+)]] were compared between the two groups.,infection and prognosis. Results After treatment,the levels of Hb,TF,Alb and PA in the low energy group were higher than those in the high energy group (P<0.05).IgA,IgG,IgM,CD3+,CD4+,CD8+ and CD4+/CD8+ in low energy group were higher than those in high energy group (P<0.05).The total infection rate in low energy group was lower than that in high energy group (5.56% vs 25.71%) (P<0.05).The good prognosis rate of low energy group was higher than that of high energy group (83.33% vs 60.00%) (P<0.05). Conclusion Compared with early high-energy parenteral nutrition support,early low-energy parenteral nutrition support has a more significant effect on patients with severe intracranial brain injury,which can significantly improve the nutritional status and immune function of patients,reduce infection rates.

Key words: different energy ratio, parenteral nutrition support, severe craniocerebral injury, nutritional index, immune function