Abstract: Objective   To investigate the effect of Qijin mixture on residual stone rate and stone recurrence after ureteroscopic holmium laser lithotripsy. Methods   A total of 108 patients with upper ureteral calculi treated in our hospital from October 2015 to October 2020 were randomly divided into control group(n=54) and study group(n=54).Patients in both groups were treated with Ureteroscopic holmium laser lithotripsy,the control group was treated with traditional natural stone removal,and the study group was treated with Qijin mixture on the basis of the control group.All patients were reexamined 3 days,1 month and 6 months after the end of treatment.The postoperative residual stone rate and postoperative complications were compared between the two groups. Results   After treatment,hematuria,abdominal pain,frequency and urgency of urination,burning sensation of urination,and the total score of TCM symptoms in the two groups were significantly lower than those before treatment (P<0.05).The symptoms of the study group were slighter than those of the control group,and the total score of TCM symptoms was lower than that of the control group (P<0.05).The total effective rate of the study group was 96.30%,which was higher than 85.19% of the control group (P<0.05).The stone clearance rate of the study group was higher than that of the control group (P<0.05).The total incidence of complications such as low back pain,fever,infection and urinary tract irritation was lower than that of the control group (P<0.05).There was no significant difference in the residual stone rate between the two groups at 3 days after operation (P>0.05).Abdominal X-ray examination 1 month after operation showed no residual stones in the study group,while 8 patients in the control group still had residual stones (P<0.05).CT examination of urinary system 6 months after operation showed no recurrence of calculi in the study group.In the control group, 5 of the 8 patients with residual stones had increased stone diameter and stone recurrence was visible, and 2 of the 46 patients without residual stones found new stones.The recurrence rate of stone in the study group was lower than that in the control group, the difference was statistically significant(P<0.05). Conclusion   Qijin mixture has a significant effect on stone removal after Ureteroscopic holmium laser lithotripsy,which can accelerate the discharge of residual stone,and reduce the incidence of complications.

Key words: Qijin mixture, ureteroscopic holmium laser lithotripsy, residual stone rate, recurrence of calculus