Abstract: Objective  Through retrospective analysis of the case data of infusion port implantation by various approaches,tried to find out the best approach for infusion port implantation. Methods  104 patients who underwent infusion port implantation from January 2019 to December 2021 in our department were retrospectively analyzed.Including internal jugular vein approach in 55 cases (group A),subclavian vein approach in 49 cases (group B),compared the differences in operative time,puncture time,catheter length,intraoperative and postoperative complications.Results  Compared with group B,the puncture time of the group A was shorter[(8.84±3.10)min vs. (11.22±3.86)min],,less bleeding[(12.64±5.63)ml vs (15.71±7.07)ml],the incidence of catheters heterotopia was low(0 vs 8.16%,all P＜0.05).There was no significant difference in intraoperative complications such as pneumothorax and postoperative complications between the two groups（P>0.05). Conclusion  The puncture time of the internal jugular vein is shorter,the success rate is higher,and the incidence of complications such as catheter heterotopia is lower,therefore,the first choice should be the right internal jugular vein.

Key words: internal jugular vein, subclavian vein, infusion port