Abstract: Objective To analyze the effect of keyhole approach and craniotomy on the recovery of patients with traumatic brain injury and cerebral hemorrhage and the expression of D-dimer and Hcy levels.Methods According to the random envelope method,65 patients with craniocerebral trauma complicated with cerebral hemorrhage admitted to our hospital from January 2014 to June 2019 were divided into observation group (n=35) and control group (n=30).The control group received traditional craniotomy hematoma evacuation,and the observation group was treated with intracerebral hematoma evacuation via keyhole approach under general anesthesia;the clinical efficacy was assessed after 4 weeks of treatment,and the neurological deficit score of the patients was assessed before and after treatment;the D-dimer and Hcy levels of the patients were measured before and after treatment.Results The total effective rate of the observation group was higher than that of the control group significantly (P<0.05);the neurological deficit score,D-dimer and Hcy in the blood of the observation group was lower than the control group significantly (P<0.05).Conclusion Compared with craniotomy,keyhole microscopy can effectively improve the clinical effect and reduce the D-dimer and Hcy level.

Key words: Craniotomy, intracerebral hematoma removal via keyhole approach, craniocerebral trauma with cerebral hemorrhage, D-dimer, Hcy