Abstract: Objective To investigate the effect of single-hole thoracoscopy in the operation resection of early lung cancer with ground-glass nodules. Methods A total of 168 patients with early lung cancer mainly represented by ground-glass nodules who received surgical resection in our hospital from January 2015 to March 2021 were selected and divided into 2 groups according to different surgical methods.The observation group included 84 invalids were received single-hole thoracoscopic radical resection of early lung cancer,while the control group included 84 invalids were received traditional three-hole thoracoscopic radical resection.The pain,perioperative conditions,changes of inflammatory reaction indexes before and after operation,quality of life before and after surgery and the incidence of complications were compared between 2 groups. Results The visual analogue scale scores of(6.12±0.93) points,(5.12±0.73) points and(3.67±0.82) points in the observation group were lower than those of(6.53±0.91) points,(6.15±0.58) points and(4.36±0.91) points in the control group at 1 day,3 days and 5 days after operation(P＜ 0.05).The average incision length of(3.91±0.46) cm and drainage tube indwelling time of(2.85±0.71) d in the observation group were shorter than those of(6.63±0.86) cm and(3.69±0.87) d in the control group(P＜ 0.05).C-reactive protein(12.39±2.15) ng/L,procalcitonin(3.34±0.39) ng/ml and interleukin-6(148.57±18.52) pg/ml in the observation group were lower than those in the control group(24.09±3.41) ng/L,(4.78±0.51) ng/ml and(163.21±19.69) pg/ml at 5 days after operation(P＜0.05).The quality of life scale of lung cancer patients in the observation group(108.41±4.26) was higher than that in the control group(103.26±3.54) at 6 months after operation(P＜ 0.05).The incidence rate of complications in the observation group(17.86%) was not statistically significant compared with 22.62% in the control group(P>0.05). Conclusion The implementation of single hole thoracoscopic radical surgery for early lung cancer patients with ground glass nodules has significant clinical effect,which can reduce the trauma to patients,reduce the postoperative inflammatory reaction and promote the postoperative rehabilitation of patients.

Key words: single port thoracoscopy, ground glass nodules, lung cancer, surgical resection of early lung cancer