Abstract: Objective To evaluate the value of continuous renal replacement therapy in the maintenance of marginal donor lungs.Methods A retrospective analysis of 30 marginal donor lungs maintained by the Lung Transplantation Center of Wuxi People’s Hospital from January 1,2019 to October 31,2019,of which 12 cases(set as the experimental group) received routine and CRRT combined program for 48 hours,and 18 cases(set as the control group) received routine maintenance.Peripheral blood samples were collected every 24 hours.Chest X-ray exam and airway bronchoscopy were performed in both groups.Results After maintenance by two methods,the quality of the donor lungs in both groups improved when compared with the previous ones.The oxygenation index in the experimental group was significantly higher than that in the control group[(93.58±16.92)% vs.(57.72±11.41)%,P<0.001)].The inflammatory indexes(CRP,PCT) were significantly decreased[(CRP:(36.04±22.30 )mg/L vs.(18.01±6.78)mg/L,P＜0.05];[PCT:(1.09±0.45)ng/L vs.(0.59±0.82)ng/L,P＜0.05)].The exudation changes and airway mucosal edema in the experimental group were significantly improved.8 cases in the experimental group and 5 cases in the control group reached the donor criteria for transplant,and the utilization rate was significantly higher than that in the control group(P＜0.05).Conclusion CRRT can significantly improve the lung function of marginal donor lungs and improve the utilization rate of donor organs. 

Key words: continuous renal replacement therapy, marginal donor lungs, lung transplantation