Abstract: Objective  To explore the expression change and clinical implication of apolipoprotein H(ApoH) in aortic dissection(AD).Methods Fifteen patients with Stanford type A aortic dissection(TAAD) in Tongji Hospital from August 2015 to January 2020 were included,and the ascending aortic tissue extracted during the operation was used as the TAAD group.Normal ascending aortic wall clipped during heart transplantation or cardiopulmonary transplantation was selected as the control group（9 cases）.The protein levels of ApoH were detected in the two groups,and Pearson correlation analysis was used to analyze the relationship between the protein levels of ApoH and the aortic diameters of patients with TAAD.Results Western blot and immunohistochemical staining showed that the expression levels of ApoH in the aortic wall of TAAD group was significantly higher than that of the control group(P<0.05).However,there was no significant correlation between the protein levels of ApoH and the aortic diameters of TAAD(P>0.05).Conclusion The protein expression of ApoH is significantly upregulated in aortic wall of patients with TAAD,suggesting that ApoH may be involved in the pathogenesis of AD.Targeting ApoH may be a potential new strategy for delaying AD.

Key words: aortic dissection, apolipoprotein H, lipid metabolism disorders