Abstract: Objective To explore the clinical significance of identification of low-density lipoprotein(LDL) and highd-ensity low lipoprotein(HDL) subclasses in the risk prediction of hepatitis B virus(HBV)-related liver cancer.Methods From January to December 2017,90 HBV carriers diagnosed and treated in the First Affiliated Hospital of the Air Force Military Medical University were prospectively included,and they were divided into liver cancer group(n=30),liver cirrhosis group(n=30) and chronic liver disease group(n=30).Serum LDL subtypes were analyzed by polyacrylamide gel electrophoresis,and serum HDL subtypes were determined by two-dimensional gel electrophoresis and western blotting.The clinical data of each group and the levels of serum LDL and HDL subtypes were compared,and the risk factors affecting the occurrence and prognosis of liver cancer were analyzed by Logistic regression model.The predictive efficacy of each index was analyzed by the receiver operating characteristic(ROC) curve.〖WTHZ〗Results Compared with the chronic hepatitis group,Small and dense(sd) LDL levels in patients with liver cirrhosis and liver cancer increased significantly,and serum HDL2 and HDL3 levels decreased significantly,both P<0.05.In addition,the serum sdLDL level of the liver cancer group was higher than that of the liver cirrhosis group,and the serum HDL2 and HDL3 levels were lower than that of the liver cirrhosis group,both P<0.05.Logistic regression analysis showed that the increase of serum sdLDL level and the decrease of HDL3 level are independent risk factors of liver cancer in patients with chronic liver disease,P<0.05.After ROC curve analysis,the area under the curve of serum sdLDL and HDL3 predicting the occurrence of liver cancer was 0.899(0.835~0.964) and 0.816(0.731~0.902),the specificities were 0.883,0.976,the sensitivities were 0.867,0.600.Conclusion Serum sdLDL and HDL3 levels are related to the risk of HBV-related liver cancer.Monitoring serum sdLDL and HDL3 levels is helpful for early diagnosis of liver cancer.

Key words: low-density lipoprotein, high-density lipoprotein, liver cancer, sdLDL