Abstract: Objective To study the expression level of PTEN phosphorylation(p-PTEN) in gastric cancer tissues,and to explore its correlation with the clinicopathological characteristics and prognosis of gastric cancer patients. Methods Collect 85 cases of gastric cancer patients who underwent radical gastric cancer surgery in our hospital from January 2015 to January2016 and were confirmed by pathology,and collected their gastric cancer tissue specimens and adjacent tissues;Immunohistochemistry was used to analyze the expression of p-PTEN in gastric cancer tissues and adjacent tissues;at the same time,according to the expression of p-PTEN in gastric cancer tissues,gastric cancer patients were divided into p-PTEN low expression group and high expression group;Compare the differences in clinicopathological data and prognosis between the two groups of gastric cancer patients,and analyze the risk factors that affect the survival of gastric cancer patients. Results In gastric cancer tissues,51cases had low expression and 34 cases had high expression of p-PTEN;in the adjacent tissue,69 cases had low expression and 16 cases had high expression.The expression level of p-PTEN in gastric cancer tissue was significantly higher than that in adjacent tissue,and the difference between the two groups was statistically significant( P <0.05).The high expression of p-PTEN was correlated with the degree of differentiation,depth of invasion,TNM stage and metastasis rate of gastric cancer patients( P <0.05).p-PTEN low expression patients were significantly shortened(χ₂=14.296, P <0.001).Multivariate Cox proportional hazards regression model analysis showed that CEA,CA19-9,TNM stage,lymph node metastasis and p-PTEN expression were independent risk factors for OS in gastric cancer patients( P <0.05). Conclusion The level of p-PTEN in patients with gastric cancer is significantly increased.The level of p-PTEN is closely related to the clinicopathological characteristics of patients with gastric cancer,and is negatively related to overall survival.

Key words: gastric cancer, PTEN phosphorylation, immunohistochemistry, overall survival