Abstract: Objective To investigate the effect of laparoscopic partial nephrectomy with renal artery occlusion (LPN) in the treatment of cT1 stage renal carcinoma (RCC) and its effect on renal function. Methods 108 cT1 RCC patients admitted from January 2014 to January 2019 were divided into LPN group and LAPAROSCOPIC radical nephrectomy (LRN) group according to surgical methods.Perioperative related indicators,postoperative renal function and complications of the two groups were compared,and the mortality of the two groups was analyzed during 2-24 months follow-up. Results In LPN group,the operative time was (120.65±20.36) minutes,the intraoperative blood loss was (124.65±19.47) ml,and the postoperative feeding time was (1.59±0.36) days.LRN group were (86.63±17.85) min,(113.64±17.74) ml and (1.18±0.32) days,respectively,and the difference between the two groups was statistically significant (P<0.05).LPN group drainage tube removal time (4.26±1.14) days,postoperative hospital stay (8.71±2.27) days,LRN group (4.03±1.02) days,(8.16±2.15) days,there was no significant difference between the two groups (P>0.05).There was no significant difference in postoperative complication rate between the two groups (P>0.05).After surgery,serum creatinine (SCr) and glomerular filtration rate (eGRF) levels in both groups were significantly higher than those before surgery (P<0.05),while SCr and eGFR levels in LPN group were significantly lower than those in LRN group (P<0.05).The mean follow-up time was (15.41±3.36) months.During the follow-up period,2 patients died in the LPN group and no death in the LRN group.There was no significant difference in mortality between the two groups (P>0.05).Conclusion LPN is as safe as LRN in the treatment of cT1 renal cancer,and LPN can effectively preserve functional nephron and reduce the risk of postoperative chronic kidney disease and cardiovascular disease.However,LPN still has the risk of incomplete tumor resection,so it is recommended to carefully evaluate the body conditions and tumor status of patients with renal cancer and select an appropriate surgical method.

Key words: laparoscopic renal artery blocking partial nephrectomy, laparoscopic radical nephrectomy, stage cT1 renal cancer;efficacy;renal function