Abstract: Objective:To analyze and compare the efficacy and safety of percutaneous mechanical thrombectomy and catheter directed thrombolysis in the treatment of acute deep venous thrombosis of lower limbs.Method:Eighty patients with lower extremity deep vein thrombosis in the Department of Vascular Surgery of our hospital from February 2018 to February 2019 were selected,and divided into percutaneous mechanical thrombectomy group and catheter directed thrombolysis group according to treatment regiments.The venous patency rate,Ddimer,complications,total usage of urokinase and length of hospital stay were analyzed in the two groups.Result:Comparison of percutaneous mechanical thrombectomy group and catheter directed thrombolysis group:Postoperative venous patency score was compared as(1.90±1.02)VS(2.16±1.10),the comparison of vein patency rate was was compared as:(85.84±11.48)% VS(84.40±14.71)%（P>0.05）.The time for Ddimer to drop to normal value:(6.30±1.23) vs(8.2±1.59) days（P＜0.05）.A small amount of various complications(including bleeding,infection,allergy,etc.) occurred during the treatment，and the differences were not statistically significant（P>0.05）.Total use of urokinase:(226±34) 10,000 units of VS(278.4±103.5) 10 000 units,the results showed significant difference（P＜0.05）.Total length of stay:(13.57±4.76) days vs(12.98±4.55) days（P>0.05）.Total hospitalization cost:(9.4±3.1) VS(4.7±2.3) 10 000 Yuan,the results showed significant difference(P＜0.05).Conclusion:Two groups showed good safety during perioperative period and could effectively clear thrombus within a short period of time.In the percutaneous mechanical thrombectomy group,the hospital stay was shorter,the use of thrombolytic drugs was less,and the Ddimer decreased faster,but the cost increased.

Key words: deep venous thrombosis, percutaneous mechanical thrombectomy, catheter directed thrombolysis