Abstract: Objective：To investigate the quality of life after total thyroidectomy for papillary thyroid carcinoma(PTC) with Hashimoto's thyroiditis(HT).Methods：The 82 patients with PTC complicated with HT underwent total thyroidectomy in our hospital from January 2015 to February 2019 were retrospectively analyzed,and the quality of life of patients 12 months after operation was statistically analyzed.Karnofsky functional status score(KPS) was used to evaluate the quality of life.Univariate analysis was used to analyze the related factors affecting the quality of life after total thyroidectomy;multivariate logistic regression analysis was used to analyze the independent risk factors of quality of life after total thyroidectomy.Results：All patients were followed up for 12 months,the average KPS score was(77.25±13.19).Univariate analysis showed that there were no significant differences in KPS scores among different gender,body mass index,underlying diseases,TSH level,TGAb positive,TPOAb positive,operation time,intraoperative blood loss,postoperative hypocalcemia,postoperative hypoparathyroidism,postoperative oral thyroxine tablets and postoperative 131I patients(P>0.05);KPS score of patients with age > 60 years old was lower than that of patients with age≤60 years old,KPS score of patients with tumor>5 cm was lower than that of patients with tumor≤5 cm,KPS score of patients with stage ⅢⅣ was lower than that of patients with stage ⅠⅡ,and KPS score of patients with lymph node metastasis was lower The KPS score of patients with extraperitoneal invasion was lower than that without lymph node metastasis(P<0.05).Multivariate logistic regression analysis showed that age>60 years old,tumor>5 cm,stage ⅢⅣ,lymph node metastasis and tumor extracapsular invasion were the independent risk factors affecting the quality of life after total thyroidectomy.Conclusion：The quality of life in patients with PTC complicated with HT after total thyroidectomy is affected by many factors,including age,tumor size,clinical stage,lymph node metastasis and tumor invasion.

Key words: papillary thyroid carcinoma, Hashimoto's thyroiditis, total thyroidectomy, quality of life