Abstract: Objective:To observe the effect of microwave ablation on immune inflammatory response and prognosis in patients with advanced lung adenocarcinoma.Methods:A total of 86 driver genenegative patients with advanced lung adenocarcinoma who were admitted to Hefei Second People's Hospital from February 2016 to February 2019 were selected and divided into a microwave ablation group and a control group according to the random number table method,43 cases each.The control group received gemcitabine + carboplatin chemotherapy,and microwave ablation treatment was added to the microwave ablation group.The changes of stress indexes,inflammation indexes,immune indexes and shortterm efficacy in both groups were observed.The patients were followed up to April 2020 to observe the survival of the two groups of patients.Results:The objective response rate(58.14%) and disease control rate(83.71%) of the microwave ablation group were higher than those of the control group(34.88%,65.12%,P＜0.05).After 4 weeks of treatment,the microwave ablation group MDA[(135.1±11.0)mg/L],SOD[(5.4±2.2)U/L],CRP[(8.3±2.5)mg/L],IL6[(76.9± 7.1)pg/ml],PCT[(5.9±1.5)ng/ml] were not statistically different from the control group[(129.6±10.9)mg/L,(5.2±2.0)U/L,(8.6±2.9) mg/L,(75.8±8.9)pg/ml,(5.1±2.0)ng/ml,P>0.05],CD4+[(44.9±5.1)%],CD4+/CD8+(1.49±0.58) in microwave ablation group after treatment were higher than the control group[(30.8±4.9)%,(1.31±0.52),P＜0.05].The followup time was 1348 months.The average followup time was(29.4±4.9) months.The successful followup rate was 94.2%.The KaplanMeier method and log rank test showed that the cumulative survival rate of the microwave ablation group was higher than that of the control group(P＜0.05).Conclusion:Microwave ablation therapy can significantly improve the shortterm efficacy and survival of advanced lung adenocarcinoma.It has high safet,improve immune function and does not affect the stress response.

Key words: microwave ablation, advanced lung adenocarcinoma, inflammatory response, stress response, immune function