Abstract: Recently,plenty of literature reported that pancreaticobiliary maljunction(PBM) was associated with biliary malignancies.With the deepening of the research,it has been found that pancreaticobiliary reflux also occurs in patients with normal pancreaticobiliary junction(occult pancreaticobiliary reflux,OPR).There are few reports on the correlation between OPR and biliary diseases up to now.The incidence of OPR is still not clear,and the clinical manifestation of OPR in the early stage is not characteristic.OPR cannot be diagnosed by routine imaging examination.However,some studies have shown that OPR was associated with a variety of biliary diseases and play a role in the development of gallbladder cancer.So related disciplines should attach importance to OPR.In this paper,we review the progress in the research of OPR.

Key words: occult pancreaticobiliary reflux, biliary diseases, biliary amylase, pancreaticobiliary junction