Abstract: Objective To compare the clinical effect of laparoscopic common bile duct exploration and stone extraction(LCBDE) combined with laparoscopic cholecystectomy(LC) compared with endoscopic retrograde cholangiopancreatography/endoscopic sphincterotomy(ERCP/EST) combined with laparoscopic cholecystectomy(LC) in the treatment of calcalous acute obstructive suppurative cholangitis(AOSC).
Methods The clinical data of 70 patients with calcalous AOSC in Songjiang Hospital affillated to Shanghai Jiaotong University School of Medicine were analyzed retrospectively.The cases were divided into the LCBDE+LC group(36 cases) and the ERCP/EST+LC group(34 cases) according to different treatment methods.The total operative success rate，primary operative success rate，operation time，intraoperative bleeding volume，postoperative complications rate，hospitalization time and hospitalization cost of the two groups were compared.
Results In LCBDE+LC group，the success rate of primary operation was higher than that of ERCP/EST+LC group，the length and cost of hospital stay were less than that of ERCP/EST+LC group，but the intraoperative bleeding volume was more than that of ERCP/EST+LC group.The difference was statistically significant(P＜0.05).There were no differences in the total operative success rate，operation time and postoperative complications rate between LCBDE+LC group and ERCP/EST+LC group(P＞0.05).
Conclusions Compared with ERCP/EST+LC in the treatment of calcalous AOSC，LCBDE+LC has the advantages of higher success rate of primary operation，shorter hospitalization time and lower hospitalization cost.

Key words: acute obstructive suppurative cholangitis, calculus, laparoscopic surgery, endoscopic therapy, curative effect