Abstract: Objective：To investigate the Changes of high mobility group protein B1(HMGB1) and Triggering Receptor Expressed on Myeloid Cells1(TREM1) in patients with arteriosclerosis obliterans after interventional therapy and Their Predictive Value.Methods：Seventy patients with cerebral infarction admitted to our hospital from January 2014 to October 2017 were enrolled.The clinical data of the patients were collected and divided into recurrent group(n=31) and nonrecurrent group(n=39) according to whether restenosis occurred within 2 years after operation.The clinical data of patients were collected,the levels of serum HMGB1 and TREM1 before and 1month after operation were measured,and the evaluation value of serum HMGB1 and TREM in predicting restenosis after operation was analyzed.Results：The levels of serum HMGB1,TREM1,LDL,hs CRP levels,and bilateral lesions were higher in the restenosis group than in the control group(P＜0.05).Spearman correlation analysis showed that serum HMGB1 and TREM1 before and 1month after operation were positively correlated with LDL and hsCRP levels of patients with cerebral infarction(P＜0.05).Multivariate logistic regression showed that preoperative serum HMGB1(>11.56ng/L) and preoperative TREM1(>203.47ng/L) as well as 1month postoperatively HMGB1(>16.08ng/L),TREM1(>266.41ng/L),LDL(>2.99mmol/L) and hsCRP(>1.96mg/L) were the risk factors for restenosis in patients with lower extremity arteriosclerosis occlusive interventional therapy(P＜0.05).The diagnostic efficiency of combined serum HMGB1 and TREM1(AUC=0.884) 1 month after operation was higher than that of combined detection before operation(AUC=0.784)(P＜0.05).Conclusion：Serum HMGB1 and TREM1 1 month after operation were highly expressed in patients with arteriosclerosis obliterans of the lower extremities,and the combination of the two at 1 month after surgery has a good predictive value for the occurrence of postoperative restenosis.

Key words: high mobility group box 1, triggering receptor of myeloid cells 1, lower extremity arteriosclerosis obliterans, interventional therapy, restenosis