Abstract: Objective：To observe the occurrence of sepsis after percutaneous nephrolithotomy(PCNL) and the predictive value of soluble triggering receptor expressed on myeloid cells1(sTREM1) combined with highsensitivity Creactive protein(hsCRP) and neutrophil to lymphocyte ratio(NLR).Methods：A retrospective analysis was performed on the clinical data of 358 PCNL patients admitted to the hospital from September 2015 to September 2020.According to presence or absence of sepsis after PCNL,they were divided into sepsis group and nonsepsis group.The influencing factors of sepsis after PCNL and the predictive value of sTREM1,hsCRP and NLR were analyzed.Results：Among the 358 patients,there were 31 cases(8.66%) with sepsis after PCNL.There were significant differences between the two groups in gender,stone diameter,staghorn stone,preoperative sTREM1,hsCRP and NLR levels,and operation time(P<0.05).AUC values of sTREM1 and NLR were 0.886 and 0.851,significantly higher than that of hsCRP(0.647)(P<0.05).AUC of sTREM1 combined with hsCRP and NLR was as high as 0.973,significantly higher than that of single index(P<0.05).The results of Logistic regression analysis showed that female gender,stone diameter not shorter than 2.5cm,staghorn stone,preoperative sTREM1 level not lower than 1.02 μg/L,preoperative hsCRP level not lower than 5.37 mg/L,preoperative NLR level not lower than 2.66 and operation time not shorter than 90 min were all independent risk factors of sepsis after PCNL(P<0.05).Conclusion：The occurrence of sepsis after PCNL is related to many factors.The combined detection of sTREM1,hsCRP and NLR is of important value for predicting the occurrence of sepsis after PCNL.

Key words: percutaneous nephrolithotomy, sepsis, soluble triggering receptor expressed on myeloid cells11, highsensitivity Creactive protein, Neutrophil to lymphocyte ratio