Abstract: Objective：To explore the safety and efficacy of laparoscopic cholecystectomy in different time points after endoscopic retrograde cholangiopancreatography in elderly patients with cholecystolithiasis and choledocholithiasis.Methods：99 elderly patients(≥60 years old) with cholecystolithiasis and choledocholithiasis treated by sequential LC after ERCP in the Department of Hepatobiliary and Pancreatic surgery in our hospital from January 2015 to June 2020 were analyzed.According to different time points after ERCP,LC was divided into experimental group(within 1 day after ERCP) and control group(within 27 days after ERCP).The complications were followed up by telephone within 3 months after operation.Results：After analysis,the difference between the experimental group and the control group in the total length of hospitalization［(13.0±4.6)d  vs(15.1±4.4)d］ and total hospitalization expenses［(38 172.5±12 448.9)  vs(42 535.4±8 814.6)］ was statistically significant(P＜0.05).However,there was no significant difference in the conversion rate of LC to laparotomy,the total postoperative complications,the length of hospital stay after LC,the amount of blood loss during LC and the time of LC operation between the two groups(P>0.05).Conclusion：For elderly patients with cholecystolithiasis and choledocholithiasis,LC within 1 day after ERCP does not increase the difficulty of operation and postoperative complications,but shortens the hospitalization time,and it is economical and safe at the same time.

Key words: elderly, choledocholithiasis, endoscopic retrograde cholangiopancreatography, cholecystectomy