Abstract: Objective To investigate the risk factors of delayed perineal incision healing after abdominoperineal resection(APR) for low rectal cancer.
Methods A total of 172 patients with low rectal cancer who underwent APR from July 2008 to June 2020 were selected as the study subjects.According to the occurrence of delayed perineal incision healing,they were divided into delayed incision healing group(42 cases) and incision healed normally group(130 cases).The gender,age,body mass index,diabetes,score of American society of anesthesiologist,preoperative hemoglobin,preoperative albumin,neoadjuvant chemoradiotherapy,size of tumor,operation mode,pelvic floor restoration,operation time,bleeding during operation and depth of tumor invasion were analyzed by univariate analysis and multivariate logistic regression analysis.
Results Univariate analysis showed that body mass index≥28kg/m2,diabetes,preoperative albumin<35g/L,neoadjuvant chemoradiotherapy and no pelvic floor restoration related to delayed perineal incision healing after APR(P<0.05).Multivariate logistic regression analysis showed that neoadjuvant chemoradiotherapy was independent risk factor of delayed perineal incision healing after APR(P<0.05).
Conclusion Patients with low rectal cancer undergoing neoadjuvant chemoradiotherapy will increase the risk of delayed perineal incision healing after APR.we should screen relevant high-risk groups before operation and take active and reasonable treatment measures to reduce the impact of delayed perineal incision healing to help patients recover.

Key words: rectal carcinoma, abdominoperineal resection, delayed wound healing, monofactor analysis, multivariate analysis