Abstract: Objective：To analyze the efficacy and quality of life of ultrasoundguided radiofrequency ablation of pleural metastases in the treatment of nonsmall cell lung cancer associated malignant pleural effusion.Method：The 101 patients with nonsmall cell lung cancer complicated with malignant pleural effusion were collected from April 2018 to April 2020.According to the doubleblind random number grouping method,the patients were divided into combined treatment group(ultrasound guided radiofrequency ablation combined with targeted thoracic perfusion,n=36),thoracic perfusion treatment group(n=30) and radiofrequency ablation group(n=35).In the radiofrequency ablation group,ultrasoundguided radiofrequency therapy was used;in the thoracic perfusion treatment group,targeted perfusion of bevacizumab into pleural cavity was used;and in the combined treatment group,ultrasoundguided radiofrequency therapy combined with local targeted pleural perfusion was used.The changes of tumor indexes(CEA,CA125,vascular endothelial growth factor expression),progression free survival time,pain score and quality of life score of patients with malignant pleural effusion before and after treatment were compared and analyzed.Result：The tumor markers CEA and CA125 of three groups of patientswere significantly decreased after treatment,the difference was statistically significant(P<0.05).The vascular endothelial growth factor decreased significantly in the combined treatment group and the thoracic perfusion treatment group after treatment,the difference was statistically significant(P<0.05).The progression free survival time of the combined treatment group was longer than that of the thoracic perfusion treatment group and the radiofrequency ablation group(P<0.05).After treatment,the VAS pain score and quality of life score improved significantly in the combined treatment group and the radiofrequency ablation group(P<0.05).There were no grade 3/4 serious side effects in the three groups after treatment.Conclusion：The ultrasound guided radiofrequency ablation combined with targeted thoracic perfusion therapy can improve the progression free survival time,down regulate the expression of vascular endothelial growth factor,and improve the quality of life of patients.

Key words: pleural effusion, ultrasound, radiofrequency ablation, thoracic perfusion, progression free survival time, growth quality score, pain score