Abstract: Objective  To analyze the risk factors and prognosis of breast cancer patients with bone metastases.
Methods  Collected 2013-2015 U.S.Surveillance,Epidemiology,and End Results(SEER) database of patients with advanced breast cancer,and analyze the risk factors of bone metastasis,and multivariate Cox regression analysis was used to analyze the independent risk factors affecting the prognosis of patients with bone metastasis.
Results  Univariate analysis showed that in patients with advanced breast cancer,bone metastasis was related to gender,age,race,histological grade,pathological type,N stage,liver metastasis,lung metastasis,ER status,PR status and HER-2 status Relevant(P<0.05);the results of multivariate analysis showed that bone metastasis was related to the patient's age,gender,tissue grade,pathological type,N stage,ER status,PR status,and HER-2 status.The overall survival rate of patients with bone metastases in advanced breast cancer patients is higher;the multivariate Cox regression model shows that the patients are older at onset,black,high tissue grade,high T stage,no surgery and chemotherapy,accompanied by brain metastasis,accompanied by Lung metastasis,liver metastasis,ER negative,PR negative,and HER-2 negative are all independent risk factors affecting the survival of patients with bone metastases.
Conclusion  Among patients with advanced breast cancer,bone metastasis have a better prognosis than non-bone metastases.The age of onset,black people,high tissue grade,high T stage,brain metastasis,lung metastasis,liver metastasis,ER negative,PR negative and HER-2 negative are independent risk factors for poor prognosis.

Key words: breast cancer, bone metastasis, SEER database, risk factors, prognosis