Abstract: Urethral injury or stricture has become a serious problem affecting health and quality of life in men.Common treatment methods,such as urethral dilatation,urethrotomy or urethroplasty,are not effective and satisfactory for patients with complex and extensive urethral injury.Therefore,researchers have tried to use tissue engineering technology to treat urethral stricture or injury and developed a large number of tissue engineering strategies related to urethral regeneration in the past few decades;they have carried out extensive research in cell source,material and method selection,and also obtained rich scientific achievements.In the future,researchers will continue to use cell sheet technology,3D bioprinting and other new methods to help the research and development of tissue-engineered urethra,expecting to be widely used in clinical practice as soon as possible and benefiting associated patients.

Key words: urethral stricture, tissue engineering, biomaterials, 3D bioprinting, urethral reconstruction